 | MSM 2000
Technical Proceedings of the 2000 International Conference on Modeling and Simulation of Microsystems
Chapter 12: Computational Methods for Microfluidics |
| | Analysis of Sample Injection and Band-Broadening in Capillary Electrophoresis Microchips |
| Authors: | S. Krishnamoorthy and M.G. Giridharan |
| Affilation: | CFD Research Corporation, U.S.A. |
| Pages: | 528 - 531 |
| Keywords: | electrophoresis, electroosmosis, microfluidics, simulation, focussing |
| Abstract: | An implicit finite-volume numerical scheme has been developed to solve the three-dimensional transport equations that govern the electroosmotic and electrophoretic phenomena. The scheme consists of solving the ion transport equation and electro-neutrality condition coupled with Navier-Stokes equations for fluid flow in a sequential fashion until convergence is achieved. This capability is used for accurate modeling of electrokinetic focussing and of sample injection in cross-channels, and band-broadening in microchips. The simulations show that sample injection using electrokinetic switching technique produces sample plug with a large tail which has been observed in experiments. The simulations also show the sample plug broadening due to turns in the separation channel. |
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| ISBN: | 0-9666135-7-0 |
| Pages: | 741 |
| Hardcopy: | $100.00 |
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