Nano Science and Technology Institute
MSM 2000
MSM 2000
Technical Proceedings of the 2000 International Conference on Modeling and Simulation of Microsystems
Chapter 12: Computational Methods for Microfluidics

Analysis of Sample Injection and Band-Broadening in Capillary Electrophoresis Microchips

Authors:S. Krishnamoorthy and M.G. Giridharan
Affilation:CFD Research Corporation, US
Pages:528 - 531
Keywords:electrophoresis, electroosmosis, microfluidics, simulation, focussing
Abstract:An implicit finite-volume numerical scheme has been developed to solve the three-dimensional transport equations that govern the electroosmotic and electrophoretic phenomena. The scheme consists of solving the ion transport equation and electro-neutrality condition coupled with Navier-Stokes equations for fluid flow in a sequential fashion until convergence is achieved. This capability is used for accurate modeling of electrokinetic focussing and of sample injection in cross-channels, and band-broadening in microchips. The simulations show that sample injection using electrokinetic switching technique produces sample plug with a large tail which has been observed in experiments. The simulations also show the sample plug broadening due to turns in the separation channel.
Analysis of Sample Injection and Band-Broadening in Capillary Electrophoresis MicrochipsView PDF of paper
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