Nano Science and Technology Institute
Nanotech 2002 Vol. 2
Nanotech 2002 Vol. 2
Technical Proceedings of the 2002 International Conference on Computational Nanoscience and Nanotechnology
 
Chapter 6: Micro and Nano Fluidic Systems
 

Separation of Long Polyelectrolytes in a Microfuluidic Channel with Constrictions: A Monte Carlo Study

Authors:F. Tessier and G.W. Slater
Affilation:University of Ottawa, CA
Pages:99 - 102
Keywords:microfluidics, electrophoresis, ratchet, DNA
Abstract:We present Monte Carlo simulation results for the motion of long linear polyelectrolytes inside a microchannel of molecular dimensions, structured as a periodic array of wells linked by narrow constrictions. Molecules are driven in the channel by a low-intensity electric field, which we model realistically by solving the Laplace equation numerically inside the channel. Our results agree with the counterintuitive experimental observation that longer molecules advance faster than shorter ones, and we show how this separation capability is related to the conformational changes of the molecule as it approaches a constriction. We further discuss possible improvements to the original channel design using pulsed fields, notably by exploiting ratchet operating modes and resonance effects. We support these new ideas with calculations in the zero-frequency limit and simulations in the finite frequency domain.
Separation of Long Polyelectrolytes in a Microfuluidic Channel with Constrictions: A Monte Carlo StudyView PDF of paper
ISBN:0-9708275-6-3
Pages:504
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