Nano Science and Technology Institute
Nanotech 2002 Vol. 2
Nanotech 2002 Vol. 2
Technical Proceedings of the 2002 International Conference on Computational Nanoscience and Nanotechnology
Chapter 5: Biotechnology

Modeling of the Deformation of Living Cells Induced by Atomic Force Microscopy

Authors:R.E. Rudd, M. McElfresh, E. Baesu, R. Balhorn, M. Alleny and J. Belak
Affilation:Lawrence Livermore National Lab.,, US
Pages:73 - 76
Keywords:finite element modeling, biological cell, cell membrane, living cell, AFM
Abstract:We describe finite element modeling of the deformation of living cells by atomic force microscopy (AFM). Cells are soft systems, susceptible to large deformations in the course of an AFM measurement. Often the local properties, the subject of the measurement, are obscured by the response of the cell as a whole. The Lagrangian finite deformation model we have developed and implemented in finite elements analysis offers a solution to this problem. The efect of the gross deformation of the cell can be subtracted from the experimentally measured data in order to give a reproducible value for local properties. This facilitates concurrent experimental e orts to measure the mechanical properties at specific receptor sites on the membrane of a living cell.
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