Nanotech 2002 Vol. 2
Nanotech 2002 Vol. 2
Technical Proceedings of the 2002 International Conference on Computational Nanoscience and Nanotechnology

Nanotechnolgy Chapter 15

Studies on a DNA Double Helicoidal Structure Immersed in Viscous Bio-Fluid

Authors: C.W. Lim and J-J Shu

Affilation: Nanyang Technological University, Singapore

Pages: 387 - 390

Keywords: biomechanical DNA model, nonlinear helicoidal model, fluid-structure interaction, nonlinear dynamical responses, DNA sequential characteristics

Abstract:
The paper aims at extending, utilising and generalising research in nonlinear dynamics of (i) spiral/helicoidal structures, and (ii) viscous, low speed fluid to biomechanical DNA fluid-structure interaction. Employing a nonlinear helicoidal model, the energy stored in a distorted Watson-Crick DNA model subjected to viscous, low speed organic fluid loading is examined. An efficient recursive numerical scheme based on the variational principle is presented. Significant dynamical responses such as energy distribution, bending and twisting of DNA model under organic fluid excitations are discussed. Matching of DNA sequential characteristics with respect to the nonlinear dynamical responses is outlined in order to reveal information regarding DNA sequencing by means of a fluid-structure dynamical approach.

Studies on a DNA Double Helicoidal Structure Immersed in Viscous Bio-Fluid

ISBN: 0-9708275-6-3
Pages: 504