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 | Nanotech 2001 Vol. 2
Technical Proceedings of the 2001 International Conference on Computational Nanoscience and Nanotechnology
Chapter 1: Computational Biology and Molecular Design |
| | Stochastic Simulations of Cell-Cell Signalling in Hepatocytes | | Authors: | M.E. Gracheva, R. Toral and J.D. Gunton | | Affilation: | Lehigh University, U.S.A. | | Pages: | 9 - 12 | | Keywords: | stochastic, intercellular, calcium waves, gap junctions, hepatocytes. | | Abstract: | We present results of a Monte Carlo simulation of stochastic effects for two models of intercellular calcium wave propagation in rat hepatocytes. Both models involve gap junction diffusion by a second messenger. In general taking into account the stochastic effects improves agreement with experiment. Both stochastic models exhibit baseline °uctuations and variations in the peak heights of Ca 2+. In addition, we find for one model that there is a distribution of latency times, rather than a single latency time, with a width which is comparable to the experimental observation of spike widths. We also Żnd for the other model with low gap junction diffusion that it is possible for cell multiplets to oscillate independently initially, but to subsequently become synchronized. |  | View paper | | ISBN: | 0-9708275-3-9 |
| Pages: | 218 |
| Hardcopy: | $100.00 |
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