Nano Science and Technology Institute
Nanotech 2001 Vol. 2
Nanotech 2001 Vol. 2
Technical Proceedings of the 2001 International Conference on Computational Nanoscience and Nanotechnology
Chapter 1: Computational Biology and Molecular Design

Stochastic Simulations of Cell-Cell Signalling in Hepatocytes

Authors:M.E. Gracheva, R. Toral and J.D. Gunton
Affilation:Lehigh University, US
Pages:9 - 12
Keywords:stochastic, intercellular, calcium waves, gap junctions, hepatocytes.
Abstract:We present results of a Monte Carlo simulation of stochastic effects for two models of intercellular calcium wave propagation in rat hepatocytes. Both models involve gap junction diffusion by a second messenger. In general taking into account the stochastic effects improves agreement with experiment. Both stochastic models exhibit baseline °uctuations and variations in the peak heights of Ca 2+. In addition, we find for one model that there is a distribution of latency times, rather than a single latency time, with a width which is comparable to the experimental observation of spike widths. We also ¯nd for the other model with low gap junction diffusion that it is possible for cell multiplets to oscillate independently initially, but to subsequently become synchronized.
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