Nano Science and Technology Institute

Nanosys, Bruker R&D Pact Eyes New Nanoscale Imaging, Mass Spectroscopy

New tools for small molecule imaging and nanoscale mass spectrometry could result from an R&D partnership announced this week between Nanosys Inc. and Bruker Daltonics Inc.

The firms have entered a broad agreement, which includes R&D collaboration on future products, as well as distribution for Nanosys’ current nanotechnology-enabled matrix-free target plates (technology it calls Capture and Analyze NALDI chips) in Bruker’s FLEX line of specialized mass spectrometers.

Combining Nanosys’ NALDI chips with Bruker’s FLEX laser desorption ionization (LDI) time-of-flight (TOF) mass spectrometry technology may "revolutionize small molecule mass spectrometry in many important areas of life science or chemical research and analysis," the partners said.

Among potential sectors that could benefit from the combination are: chemistry and molecular biology research, molecular diagnostics and molecular imaging research, and many sectors for industrial research and analysis, including pharma/biotech, food analysis, and environmental analysis and toxicology.

Under the terms of the agreement, the companies will collaborate on R&D related to the NALDI chips, as well as on applications and assay development. Nanosys will manufacture and exclusively supply NALDI chips for Bruker LDI-TOF mass spectrometers, while Bruker Daltonics will market and distribute the chips worldwide.

NALDI chips promise significant sensitivity, throughput, and ease-of-use benefits for the analysis of small molecules. Previously, these molecules typically had to be analyzed with LC-MS (liquid chromatography-mass spectrometry), which is time-consuming, less robust, and requires more operator training.

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