Formation of Polymer Nano-particles in Supercritical Fluid Jets
The supercritical antisolvent (SAS) process is an emerging technology for the production of micro- and nanometersized particles for a wide variety of bio-medical pharmaceutical applications . In this paper, polyvinylpyrrolidone (PVP) nanoparticles are synthesized using dichloromethane (DCM) and acetone as organic solvents to prepare polymer solution and carbon dioxide in supercritical phase is used as an antisolvent. Several capillary nozzles from 20 µm to 127 µm are used to inject the solution at different Reynolds number. Particles from sub-micron size to nano size are obtained depending upon operating parameters.