Photothermal Characteristics study of PEGylated Gold Nanorods
T-Y Shih, J-T. Lin, C-C Tien, P-L Tseng, Y-H Chen
Industrial Technology Research Institute, TW
Keywords: gold nanorods, photothermal therapy, PEGylation
Abstract:Gold nanorods have a growing role in a diversity of medical applications especially in the area of hyperthermal therapy of tumor. Since localized temperature rising by laser irritation gold nanorods at near-IR frequency can induce tumor damage because of cancer cellís susceptibility to hyperthermal effect than healthy cell, moderated rise of local temperature and optimal photothermal efficiency are crucial. Here in the present work, gold nanorods were first synthesized and modified within different molecular weight of polyethyleneglycol ranging from 1000~5000. PEGylated nanorods were irritated and evaluated their photothermal effects. In order to achieve temperature optimization, we have also employed multi-wavelength laser diode system at various wavelengths (785 nm, 808 nm, and 852 nm) and power (100 mW~500 mW) to the target nanorods separately or combined for maximum hyperthermal effect. It is found that the highest temperature increase may be achieved by at certain wavelength combination near maximum absorption peak of nanorods than by single wavelength. This study will provide optimal photothermal effect and benefit further design of effective heating for hyperthermal therapy.