Bionanoparticles and Their Assemblies for Biomedical Applications
University of South Carolina, US
Keywords: bionanoparticle, virus, self-assembly, drug delivery, tissue engineering
Abstract:Plant viruses and bacteriophages can be considered as nature bionanoparticles that can be tailored chemically and genetically. Compared with the other synthetic nanoparticles, the uniform shape and size of bionanoparticles provide highly promising possibilities in self-assembly study for the construction of nanoscale materials with hierarchical ordering. On the basis of the surface modification with conventional bioconjugation chemistry, “click” reaction, and genetic modification, we can control the self-assembly of spherical and rod-like bionanoparticles to form 1D, 2D and 3D structures. Such novel nanomaterials can be employed to probe and modulate cellular response and signaling pathways. These studies will lead to direct applications including intelligent implants, tissue engineering and regeneration, and self-healing scaffolds. In particular, this talk will focus on a practical process to synthesize raspberry-like composite colloids based on the non-covalent interactions of bionanoparticles and polymers. This is a reversible process and the size of the composite colloids can be readily controlled. These results open up a unique way to assemble biomacromolecules with polymers to get hierarchical structures for developing new materials. Moreover, it can be applied in designing novel delivery vehicles for treating the brain metastatic breast cancer.