NSTI Nanotech 2009

Nanotoxicity Assessment toward the Applications of Carbon Nanotubes as a Small Biomolecule Carrier in Drug Delivery Systems

R. Sharma, S. Kwon, R. Baktur, A. Sharma
Utah State University, US

Keywords: nanotoxicity, carbon nanotube, fullerene, drug carrier

Abstract:

Carbon Nanotube (CNT) materials has superior properties in electric current carrying capacity, thermal conductivity, and thermal stability. Due to their structure with high aspect ratio, they have structural unusual toxicity and complicate safety issue in a target tissue. In optimized quantities with limited functionality, special type of CNT assembly such as “buckyball” can be used as a potential drug carrier of bioactive molecules and display with increased circulating time and acceptable functionality. We analyzed cytoxicity, macrophage action, and inflammatory response following exposure of different size, mass, shape, and functionality of CNTs. We monitored the physiological perturbation of transepithelial electrical resistance (TER) during the exposure of different concentrations of CNTs. The mechanisms of CNTs’ toxicity are closely related to their structure, functional group, and surface charge. We established the nanotoxicity of fullerenes of CNTs:
 
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