Synergistic Effect of Co-Exposure to Carbon Black and Fe2O3 Nanoparticles
B. Guo, S. Drake, R. Zebda, C. Sayes
Texas A&M University, US
Keywords: reduction capacity, protein oxidation, uptake, bioavailability, lung epithelial cells
Abstract:Synergism may play a very important role in particle toxicology, given that co-exposure to multiple particle types is highly probable in the environment or at the workplace. In this study we determined the synergistic protein oxidation effect of co-exposure to Fe2O3 and carbon black particles. For the first time, a hypothesis is proposed, which states that the reduction of Fe3+ ions by carbon black particles plays a significant role in the synergistic biological effects of particles, through the oxidative stress paradigm. This hypothesis was supported by the experimental results. This hypothesized synergistic toxicology mechanism may prove very important, given the high likelihood of simultaneous exposure to both carbon black nanoparticles (and other types elemental carbon particles) and transition metal nanoparticles. This work may have strong impact in the field of nanotoxicology by introducing a novel and potentially critical particle toxicology concept with supportive experimental evidence.