Graphitic Shelled Magnetic Nanoparticles as Localized RF Absorbers for Cancer Therapy
Y. Xu, M. Mahmood, Z. Li, E. Dervishi, S. Trigwell, V. Saini, A.R. Biris, A.S. Biris
University of Arkansas at Little Rock, US
Keywords: magnetic nanoparticle, radio frequency, HeLa Cell
Abstract:Three types of graphite shell-magnetic core nanoparticles (Fe, Co, Fe/Co) were synthesized by radio frequency-catalytic chemical vapor decomposition (RF-CCVD) method. X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) analysis indicated that these metallic nanoparticles (NPs) inside the carbon shells were all preserved in the metallic states. Fluorescence Microscopy images and Raman spectroscopy revealed effective penetrations of the NPs through the cellular plasma membrane of the cultured HeLa cells, both inside the cytoplasm and in the nucleus. Low radio frequency (RF) radiation of 350 kHz induced localized heat into the metallic nanoparticles, which triggered the killing of the cells, process that was found to be RF application time and nanoparticles concentration dependent. Fe NPs showed the highest efficiency for the HeLa cells apoptosis compared to Fe/Co alloy and Co by itself, due to their different magnetic properties which were analyzed by (Superconducting Quantum Interference Device) SQUID. The process described in this research has significant promise for various medical therapies and efficient ablation of tumors.