In Vivo Toxicity Study of Gold Composite Nanodevices for use in Imaging and Radiotherapy
M.K. Khan, B. Nair, V. Kasturirangan, M.S.T. Kariapper, S.S. Nigavekar, K. Toth, Y.M. Rustum, A. El-Jawahri, R. Bizimungu, W. Lesniak, L.P. Balogh
Roswell Park, US
Keywords: invivo toxicity, nanocomposite, dendrimer
Abstract:We previously reported on the in vitro toxicity assessment of differently charged dendrimer-gold nanocomposites on normal cells (human endothelial cells) and prostate cancer cells (Khan et al., 2008). In this study we evaluate the in vivo toxicity of differently charged dendrimer-gold composite nanodevices in mice. In vivo clinical toxicity study includes daily observation and behavior of mice, weight, Hematologic assessment of blood, serum clinical chemistry analysis, and histological examination of organs that are collected after periods of 2 weeks (acute toxicity) and 3 months (late toxicity).We have shown that even though certain nanodevices appeared to have the potential for toxicity in vitro, they do not appear to show any measureable toxicity in vivo.