Chemiluminescent Solid Lipid Nanoparticles and Interactions with Intact Skin
J.B. Patrone, H. Le, J. Breidenich, L. Kelly, J.J. Benkoski, J.L. Sample
Keywords: chemiluminescent, lipid, nanoparticle, skin
Abstract:The utilization of nanomaterials for biosensing applications has great potential for early disease detection. Overproduction of hydrogen peroxide is implicated in the development of many diseases, including the damage caused to skin by exposure to ultraviolet radiation. In this study we have demonstrated the synthesis and characterization of solid lipid nanoparticles, often used as drug delivery vehicles, as the matrix for targeted delivery of chemiluminescent compounds to the epidermis, for detection of native peroxides. We have characterized the relationships of various aspects of our formulation with the longevity and detectability of its chemiluminescent signal.