On the Rational Design of nano-sized Particulate Systems for Vascular Targeting
S.-Y. Lee, F. Gentile, M. Ferrari, P. Decuzzi
University of Texas Health Science Center Houston, US
Keywords: multiscale modeling, adhesion, internalization, transport, nanoparticle
Abstract:Over the last decades, the treatment of cancer has relied primarily on the use of various forms of cytotoxic chemotherapy and radiation therapy. These treatments have had profound positive results only on few solid tumors. Generally, the efficacy of anticancer therapies and imaging are mainly delivery limited and this holds true even for diseases other than cancer. The use of nano-sized particulate systems (nPS)is emerging as a powerful tool. This work will present a mathematical framework integrating the three events cited above to predict the behavior in the vasculature of nPSs with a characteristic size ranging from few hundreds of nanometers to few microns; with a sufficiently arbitrary shape (ellipsoidal, discoidal, cylindrical, hemispherical and so on), and different surface physicochemical properties. At the interface between target cells and nPSs, both specific and non-specific interactions will be considered accounting for different type and density of ligand-receptor bonds in the first case and for van der Waals as well as steric repulsive forces in the second case.