Biosafety of Nanoparticles: Rapid Profiling of Relative Risk
M. Theodore, B. Nelson Ph.D., M. Dizdaroglu, J. Jackman
Johns Hopkins University Applied Physics Laboratory, US
Keywords: biosafety, risk profiling, surrogate biomarkers
Abstract:Nanotechnology and nanoparticle manufacture is expanding its area of influence. A variety of shapes and surface chemistries of nanoparticles exists at this time; however, little can be predicted regarding the contribution of these characteristics to human health. To address this knowledge gap we have compiled a suite of assays to determine if biomedically-relevant, well characterized nano-materials cause damage to genomic DNA and if the observed DNA damage is correlated/associated with cytotoxic stress in well-characterized cell systems.