Polymeric membrane carbon nanotube devices for targeted drug delivery
A. Kulamarva, M. Malhotra, A. Paul, S. Prakash
McGill University, CA
Keywords: carbon nanotubes, microencapsulation, drug delivery, targeted delivery
Abstract:Research in nanotechnology has yielded several innovative technologies and materials with significant biomedical applications. Carbon nanotubes (CNTs) are one of the most promising among nanomaterials that are being explored for use in drug delivery and diagnostics. They can be functionalized with a variety of biomolecules and used for drug delivery. Convenient and effective delivery of functionalized CNTs to targeted site faces several limitations. In order to address this we have developed a novel polymeric membrane microcapsule carbon nanotube device for targeted delivery of therapeutics. CNTs were encapsulated in an alginate-poly-L-lysine-alginate (APA) membrane to form a polymeric membrane targeted drug delivery device. The nanotubes were embedded in the core or attached to the surface of different types of alginate capsules. The incorporation of carbon nanotubes in the alginate microcapsules were determined by Raman spectroscopy and the surface characterization was performed by scanning electron microscopy. The device can be functionalized with targeting ligands for specific disease/sites of the system along with the therapeutic moiety to improve the clinical efficiency. The polymeric membrane protects the functionalized carbon nanotubes carrying the therapeutics from the harsh external environments faced during drug delivery. This novel approach facilitates delivery of carbon nanotubes and their cargo safely and effectively to target loci.