Fashioning of Polymer Multi-functional Nanovector Microparticle Delivery System by High Definition Microextrusion
P.D. Gabriele, A. Hogan, J. D’Ottavio, M. Flemmens, M. Weir
ARmark Authentication Technologies, LLC, US
Keywords: high definition microextrusion, microcarrier, nanocarrier, multifunctional targeting strategy, stable polymeric microparticle
Abstract:Considerable advances have recently been achieved in the development of nano-scale particles for cancer diagnostics and therapies. ARmark Authentication Technologies, LLC has developed a new technology platform to produce stable multifunctional polymeric microcarrier delivery vehicles for nanoparticals and bioagents. HDME offers microvector precision control of spherical geometry. Particles produced by this method show a narrow particle size distribution. The uniformity of shape and size is significant to microparticle precision pharmacokinetics. The HDME process allows the active pharmaceutical ingredient (API) to be directly loaded into spatially resolved domains throughout the particle geometry. Sensitive bioagents can likewise be incorporated through a post-absorption enhancement step. The microvector design is consistent with Ferrari’s stable-core-constituent multicomponent targeting strategy in nanobiotechnology delivery. In this study, a model biomimetic radio frequency (RF) enhanced “microvector” was fashioned under high definition micro-extrusion (HDME). The HDME technology provides options to alternative platform design and delivery system architecture, for instance, targeted hyperthermia and diagnostic imaging in cancer treatment. The proprietary ®mark microvector platform can also be constructed into other geometric forms such as ellipses, cylinders or microneedles.