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Phage-Based Patient-Specific Navigation Systems |
| Susan L. Deutscher
Associate Professor of Biochemistry
University of Missouri
| Educational BackgroundBS, Purdue University, West Lafayette, Ind., Cell Biology
PhD, St. Louis University, St. Louis, Mo., BiochemistryNotable Honors and ServiceCo-Director, NIH/NEI Center for Single Photon-Emitting Cancer-Imaging Agents
Veterans Administration Research Merit Award (1994-1996; 1998-2010)Research DescriptionOur laboratory is interested in discerning the role of carbohydrate and protein-protein interactions in cancer. Work focuses on applying novel combinatorial phage display approaches and structural biochemistry to characterize these interactions. Combinatorial chemistry and phage display allows for the rapid selection from many millions of sequences to find peptide molecules that bind almost any given target such as cancer antigens. We have isolated peptides that are being utilized to specifically modulate cancer cell adhesion events. Once radiolabeled, the peptides will prove valuable as selective cancer imaging and therapeutic agents.Speaking in the special symposium on Phage Nanobiotechnology.
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