2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

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TechConnect Summit
Clean Technology 2008

A Micro-Implant based on MEMS (Micro-Electro-Mechanical-Sysems) Technology for Treatment of Hemorrhagic Shock in Ambulatory Settings

N.M. Elman, H-L. Ho Duc, M.J. Cima
Massachusttes Institute of Technology, US

Keywords:
drug delivery, MEMS

Abstract:
An implantable drug delivery device based on MEMS (Micro-electro-Mechanical-Systems) technology was developed as a micro-implant to treat hemorrhagic shock. The device was tailored for ambulatory settings and is intended for in vivo use in the peritoneum for individuals at high risk. The implantable microchip was designed to deliver vasopressin, a known vasoconstrictor that significantly decreases mortality rates of patients suffering from internal hemorrhage. The drug delivery mechanism is based on controlled bubble nucleation for jetting drug inside of a reservoir through a hermetic membrane seal into the targeted internal organ. The design was customized for low power consumption and small size. The dimensions of the micro-implant are 5 mm wide, 8 mm long and 5 mm thick. The device was fabricated using standard micro-machining techniques that yield a mass-producible, cost-effective process that can be integrated with electronic devices. Experimental results show in vitro operation of the device delivering 25 L of a dye solution used as a test payload, in approximately 90 seconds, with an applied dc voltage of 10 V at a current of 190 mA. The micro-implant was designed for integration with a commercial small battery, a capacitor circuit and a wireless receiver. The supporting electronics will provide the required pulse signal for triggering the activation upon receiving the command from an external sensory unit that will monitor heart rate and blood pressure. The micro-implant can also provide a miniaturized solution for a number of treatments that involve high risk individuals requiring immediate treatment to increase survival rate, i.e. treatment of strokes and heart attacks. We believe that the biomedical applications of this research work will be extremely valuable to increase survival rate in numerous high risk individuals who require immediate ambulatory treatment.


Nanotech 2008 Conference Program Abstract