TATp-bearing Immunoliposomes for In Vivo Gene Delivery to Ischemic Myocardium
Y.T. Ko, W.C. Hartner, A. Kale, V.P. Torchilin
Northeastern University, US
TAT peptide, Gene Delivery, Ischemic myocardium
This study demonstrates the feasibility of in vivo gene delivery to ischemic myocardium using double-targeted delivery systems capable of extracellular accumulation and intracellular penetration. Application of liposomes modified with cell-penetrating TAT peptide (TATp) and additionally decorated with anti-myosin antibody 2G4 specific towards ischemically damaged cardiomyocytes for targeted gene delivery to ischemic myocardium was accessed in vitro with hypoxic cardiomyocytes, and in vivo using experimental myocardial infarction model in rats.
Nanotech 2008 Conference Program Abstract