2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

Partnering Events:

TechConnect Summit
Clean Technology 2008

The Design of Better Vascular Stents through Nanotechnology

J. Lu, D. Khang, C. Yao, K.M. Haberstroh, T.J. Webster
Brown University, US

Keywords:
nano, sub-micron, titanium, roughness, cell adhesion

Abstract:
Bio-inspired nano-materials might provide a promising alternative for current drug-eluting vascular stents. However, previous reports [1] have been unclear towards the contribution of implant nano surface roughness on cell functions because such materials also change in terms of their surface chemistry and most of these surface structures are meta-structure systems composed not only of nano surface structures (less than 50nm in the lateral and vertical scales) but also of sub-micron scale structures (features larger than 100nm in the lateral scale). Therefore, it has been unclear whether specifically small nano surface structures is a meaningful contributing factor for enhancing tissue forming cell responses. In this manner, the objective of this in vitro study was to modify the size of titanium surface features from flat and nano to sub micron scale (root mean square (RMS) roughness values RMS ranging from 0-12nm) and compare the initial endothelial cell adhesion to flat titanium surfaces of identical chemistry. Furthermore, different titanium surface structures were aligned to determine the possible selective and spatial control of endothelial cell adhesion.


Nanotech 2008 Conference Program Abstract