2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

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Clean Technology 2008

Numerical Analysis of Nanofluidic Sample Preconcentration in Hydrodynamic Flow

Y. Wang, K. Pant, W. Diffey, Z. Chen, S. Sundaram
CFD Research Corporation, US

Keywords:
streaming potential, nanofluidic, electric double layer, preconcentration

Abstract:
This paper presents the first, high-fidelity numerical study of nanofluidic streaming potential-based sample preconcentration. Parametric analysis is performed to capture the critical effects of pressure and background electrolyte (BGE) concentration on preconcentrator performance. Our studies demonstrate that ion-polarization and electric field barrier can be established at micro-nano-channel interfaces and substantial sample enrichment (>10,000-fold) can be readily achieved using hydrodynamic flow. The results can be used for practical design and operational protocol development for novel sample preconcentrators.


Nanotech 2008 Conference Program Abstract