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Rapid Screening of Nanoparticles for Discovery of Biomarkers
S.K. Sundaram, T.J. Weber, B.J. Riley, B.M. Webb-Robertson
Pacific Northwest National Laboratory, US
Keywords:
nanoparticle, silica, toxicity, biomarker, FTIR
Abstract:
Engineered nanomaterials are entering the market place at a rapid pace. This challenges researchers and regulators alike. Exposure to nanomaterials may occur by oral, dermal, inhalation, and injection routes, depending on use patterns. Therefore, fast, accurate, cost-effective, and portable technologies are essential for understanding and regulating the exposure and risk. Vibrational spectroscopy is a viable tool that can be used in combination with established and new toxicological and biological tools. We have developed attenuated total reflection (ATR)-Fourier transform infrared (FTIR) spectroscopic approach to screen nanoparticles. Preliminary results of screening silica nanoparticles for toxicity will be presented.
Nanotech 2008 Conference Program Abstract
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