Amphoteric liposomes are a platform for multi-organ delivery of oligonucleotides
C. Reinsch, U. Rauchhaus, S. Panzner
novosom AG, DE
siRNA, delivery, in vivo, liposomes
Oligonucleotides (ONs) such as antisense (ASO) or siRNA have created a need for new technologies that further enable the systemic and targeted delivery of these active principles. Here, we describe amphoteric, fully charge-reversible liposomes as a novel carrier concept that overcomes the limitations in biodistribution of cationic vectors systems while keeping functionality.
Nanotech 2008 Conference Program Abstract