2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

Partnering Events:

TechConnect Summit
Clean Technology 2008

Effect of Medical Device Substrate Material on Nanoparticulate Silver Efficacy

B.J. Dair, K.M. Kennedy, R.S. Casas
FDA, US

Keywords:
nanoparticle, silver, antimicrobial, medical device, polymer

Abstract:
Silver is one of the oldest known natural antimicrobial materials, the active form being the Ag+ ion, which disrupts critical cell functions in bacteria. Reducing the size of silver particles to the nano-scale regime increases the surface area and hence the availability of silver ions, thereby enhancing their potential antimicrobial efficacy relative to their bulk counterparts. Nano-particulate silver systems have been used as anti-microbial agents for medical device applications such as bandages, wound dressings, surgical masks, endotracheal tubes, and catheters. However the surface onto which the silver nanoparticles are deposited will impact the availability of Ag+ ions due to the chemistry of the substrate surface and its affinity for silver ions. The effect of substrate material on the efficacy of nanoparticulate silver will be discussed, along with the implications of materials selection in medical device applications.


Nanotech 2008 Conference Program Abstract