2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

Partnering Events:

TechConnect Summit
Clean Technology 2008

Multifunctional Polymeric Nanosystems for EGFR Gene Silencing

S. Pai, M. Amiji
Northeastern University, US

Keywords:
muiltifunctional polymeric nanoparticles, siRNA

Abstract:
Multifunctional polymeric nanoparticles with an average size of 200nm could be prepared using the solvent displacement technique. Cetyltriethylammonium bromide (CTAB) surface-modified poly(ethylene oxide)-modified poly(epsilon-caprolactone) (PEO-PCL) nanoparticles encapsulated PTX and siRNA with a loading efficiency > 95%. The multifunctional polymeric nanoparticles could successfully deliver siRNA and chemotherapeutic drug simultaneously to cancer cells to silence EGFR and enhance cell kill respectively


Nanotech 2008 Conference Program Abstract