2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

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Clean Technology 2008

Influence of water-soluble polymers and surfactants, on mebendazole solubilization by _- and permethyl-_-cyclodextrins

O-M. Ba, M. Lahiani-Skiba, S. Joudieh, F. Bounoure, M. Skiba
Université de Rouen, FR

Keywords:
water-soluble polymers, surfactants, Cyclodextrins

Abstract:
The objective of this work was to determine the influence of pH, water-soluble polymers and surfactants on mebendazole solubilization by beta- and permethyl-beta-cyclodextrins (beta-CD and PM-beta-CD). Mebendazole is an antihelmintic active drug used against a variety of intestinal parasites and potentially active against extra-intestinal parasitic infections. However, its low solubility renders it difficult to use. Cyclodextrins (CD) are able to increase the apparent solubility of poorly water-soluble active drugs by forming complexes


Nanotech 2008 Conference Program Abstract