2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

Partnering Events:

TechConnect Summit
Clean Technology 2008

Mesoporous Silica Particles Induce Size Dependent Effects on Human Dendritic Cells

H. Vallhov, S. Gabrielsson, M. Strømme, A. Scheynius, A.E. Garcia-Bennett
Karolinska Institutet, SE

Keywords:
mesoporous materials, size-dependency, co-stimulatory molecules, dendritic cells, toxicology

Abstract:
The effects of mesoporous silica nano- (270 nm) and microparticles (2.5 µm) with surface areas above 500 m2/g were evaluated on human monocyte derived dendritic cells (MDDC). Size- and concentration-dependent effects were seen, where the smaller particles and lower concentrations affected MDDC to a minor degree compared to the larger particles and higher concentrations, both in terms of viability, uptake and immune regulatory markers. Our findings support the further development of mesoporous silica particles in drug and vaccine delivery systems.


Nanotech 2008 Conference Program Abstract