2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

Partnering Events:

TechConnect Summit
Clean Technology 2008

Monofunctional Gold Nanoparticles-Synthesis and Applications in Nanomedicine

Q. Dai, X. Liu, J. Zou, Q. Huo
Nanoscience Technology Center, University of Central Florida, US

Keywords:
monofunctional gold nanoparticles, amyloid peptides, photothermal therapy

Abstract:
Bioconjugated nanoparticles and quantum dots are among the most exciting nanomaterials with promising application potentials in nanomedicine field. These applications include biosensing, bioimaging, bioassay, targeted drug delivery and new therapeutic agents or method development. However, a significant challenge in nanoparticle field is the controlled chemical functionalization of nanoparticle materials. Due to the presence of multiple reactive sites on a nanoparticle surface, it is extremely difficult to control the number and geometrical distribution of chemical functional groups on the nanoparticle surface. Recently we developed a unique solid phase place exchange reaction to synthesize gold nanoparticles with a single carboxyl functional group on the surface. The as-synthesized monofunctional gold nanoparticles can be used to conjugate with biomacromolecules, peptides to form one-to-one stoichiometrically controlled bioconjugates, or react with polymers to form sophisticated nanostructures with tunable optical properties. Specifically, we will present an example of using the monofunctional gold nanoparticles conjugated to -amyloid peptides for photothermal ablation of -amyloid aggregates. The general significance of the monofunctional nanoparticles in nanomedicine and other areas of nanomaterials research will be elaborated in details during the presentation.


Nanotech 2008 Conference Program Abstract