Molecular Imaging by Nanoparticle Bacterial delivery Systems:

Keywords:
nanoparticles, bacterial delivery system, imaging

Abstract:
Dynamic observations have driven the course of imaging biology ever since the first bacterial motility was observed in the late sixteenth century. Continuous imaging of time dependent bacterial motion events is a rapidly emerging biomedical research discipline that extends such observations in living subjects to track the cell trafficking to a more meaningful dimension. Use of paramagnetic properties of nanoparticle may be defined as the visual representation, characterization, and quantification of bacterial processes at the subcellular levels within intact living microorganisms. It is a novel multidisciplinary field, in which the images produced reflect cellular and molecular pathways and in vivo mechanisms of metabolic changes present within the context of physiologically authentic environments. The term “bacterial delivery” and nanobio-imaging” implies the convergence of localized bacterial tracking by using paramagnetic agents sitting inside bacteria using multiple image-capture techniques, basic cell/molecular biology, chemistry, medicine, pharmacology, medical physics, biomathematics, and bioinformatics into a new imaging paradigm.

Nanotech 2008 Conference Program Abstract