2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

Partnering Events:

TechConnect Summit
Clean Technology 2008

Vertically Arranged Gold Nanowires: An Interface for Live Neuronal Recordings

S. Saha, D.M. O’Malley, L. Menon
Northeastern University, US

Keywords:
calcium, electrical, nanowire, neuron, resolution

Abstract:
An understanding of the dynamic communication of neural networks in the brain has been a critical challenge to neuroscientists. The potentials of nanotechnology have opened a new technical dimension with which to effectively investigate live neural networks. The development of vertically arranged gold nanowire arrays fabricated by means of electrodeposition inside electrochemically-prepared nanoporous aluminum oxide templates is being tested in its efficacy to stimulate and detect electrical activity at the nanoscale level from simultaneous locations in neurons. Concurrent fluorescent calcium imaging will allow us to (1) visualize the patterns of neuronal activity induced by the nanowire array, and (2) evaluate the ability of the array to detect neuronal firing patterns that are observed with the calcium imaging. In addition we are studying the cell morphology and axonal outgrowth of primary rat hippocampal neurons as they interact with these orthogonally arranged gold nanowires. This type of a neural-wire array interface may allow us to investigate living neural networks in precise detail, tracking small changes in cell structure and electrical activity in a minimally invasive fashion and at the same time with excellent spatial and temporal resolution. Furthermore, this type of neural device could augment the functions of neuroprosthetic devices in patients who suffer from loss of motor abilities subsequent to injury or disease.


Nanotech 2008 Conference Program Abstract