2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

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TechConnect Summit
Clean Technology 2008

Encoding High Throughput Suspension-based Biotechnology Assays Using Digital Magnetic Microtags

T. Mitrelias, T. Trypiniotis, F. van Belle, K.P. Kopper, S.J. Steinmuller, J. Palfreyman, P.R. Robertson
Visiting Scientist, UK

Keywords:
digital magnetic tagging, biodetection, clinical diagnostics, magnetic biosensors

Abstract:
Microarrays and suspension-based technologies have attracted significant interest in the last years for their broad applications in medical diagnostics, gene sequencing and clinical diagnostics. However, the throughput of microarrays will always be limited by the array density, while suspension-based technologies offer a conceptually different approach due to their ability to extend the detection capability by expanding the size of the chemical library (probes), but are currently limited by the number of distinct codes the beads can carry. We are developing a novel encoding method based on digital magnetic labels that are remotely encoded and decoded as they flow in microfluidic channels, by means of an external magnetic read/write head. The microlabels consist of a substrate and magnetic microbars that are individually addressable by the external magnetic device and can be functionalized with various chemical or biological probes. Magnetic encoding of chemical libraries prepared by combinatorial chemistry methods is advantageous due to the possibility for encoding unique codes on each solid support during the synthesis of the library and the possibility for providing a very large number of distinguishable codes. The synthesis of the molecular compounds takes place directly onto the surface of the magnetic tag that carries the code.


Nanotech 2008 Conference Program Abstract