2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

Partnering Events:

TechConnect Summit
Clean Technology 2008

Phage-based Biorecognition Interfaces in Biosensors

B.A. Chin
Auburn University, US

Keywords:
phage-based, biorecognition interfaces, biosensors

Abstract:
As a new bioselective material, landscape phages combine unique characteristics of affinity reagents and self-assembling proteins. Biorecognition layers formed by the phage-derived probes bind biological agents with high affinity and specificity and generate detectable signals in analytical platforms. The performance of phage-derived materials as biorecognition interface was illustrated by detection of Bacillus anthracis spores, Salmonella typhimurium cells and other pathogens. With further refinement, the phage-derived analytical platforms for detecting and monitoring of numerous threat agents may be developed, since phage interface against any bacteria, virus or toxin may be readily selected from the landscape phage libraries. As an interface in the field-use detectors, they may be superior to antibodies, since they are inexpensive, highly specific and strong binders, resistant to high temperatures and environmental stresses.


Nanotech 2008 Conference Program Abstract