2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

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Clean Technology 2008

Evaluation of the paromomycin loading characteristics in nanoprecipitated PLGA nanospheres

S. Kalimouttou, M. Lahiani-Skiba, N. Naouli, V.S. LIN, M. Skiba
Université de Rouen, FR

Keywords:
paromomycin, PLGA, nanospheres, Physico-chemical characterization

Abstract:
The aim of this work was to optimize the preparation of poly(lactic-co-glycolic acid) (PLGA) nanoparticles loaded with paromomycin by a nanoprecipitation technique. PLGA was choosen because of its biodegradability and biocompatibility features. In order to improve the delivery system, especially the drugs loading efficiency, the influences of the amount of polymer and the volume of the organic phase on the characteristics of the nanospheres were assessed. Physico-chemical characterization of the loaded nanoparticles was performed.


Nanotech 2008 Conference Program Abstract