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Selective Identification of proteins by laser desorption ionization mass spectrometry on photonic nanodevices coupled to abiotic receptors
R.P. Meagley
ONE Nanotechnologies, LLC, US
Keywords:
nanodevice arrays, MALDI, SELDI, biomarker screening
Abstract:
Matrix Assisted Laser Desorption Ionization Mass Spectroscopy (MALDI MS) is a particularly efficient tool for proteomics research and diagnostics with protein biomarkers. Recent innovations in the application of inorganic matrices have enabled a reduction in noise and concomitant increases in sensitivity. However, these inorganic matrices suggest even powerful new tools may be possible. Presented here are new classes of photonic nanodevice and device arrays for biomarker screening by laser desorption ionization mass spectrometry. Integration of abiotic recognition and analysis elements into the highly sensitive MALDI technique for biomarker assay and discovery, as well as extension to other chemistries including small molecules, biopolymers and nanomaterials, and the incorporation of these effects into more complex device design and integration strategies.
Nanotech 2008 Conference Program Abstract
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