Pharmacokinetic Approach to Developing Occupational Exposure Guidelines for Single and Multiwall Carbon Nanotubes
C.E. Mackay, J. Hamblen
nanomaterials, nanotubes, occupational health, pharmacokinetics, risk assessment
The current occupational standard in the United States is based on synthetic graphite with a permissible exposure limit of 5 mg/m3. Recent instillation studies show that exposure to high concentrations of single-walled carbon nanotubes resulted in the manifestation of acute fibrosis and associated granulomas. In our investigation, the potential risk for an adverse impact based on inhalation of single and multiwall carbon nanotubes is assessed using currently available animal studies. Discussion includes evaluation of the appropriateness of the current information base and how the model can be modified and applied as more data on the toxicology of carbon nanotubes become available.
Nanotech 2008 Conference Program Abstract