2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

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Nanostructure of pharmaceutical systems studied by synchrotron and neutron radiations

M. Kumpugdee-Vollrath, H. Bilek, K. Gei├čler, U.M. Heckoetter, S. Roth, A. Hoell, I. Zizak
Professor of Pharmaceutical Technology, DE

Keywords:
Nanotechnology, drug delivery, synchrotron, neutron, SAXS, SANS

Abstract:
This present work focuses on characterization of different drug delivery systems e.g. liposomes, lipid emulsions and nanoparticles. Their structures up to nanoscale will be demonstrated. The techniques e.g. small and wide angle x-ray scattering (SAXS, WAXS) and grazing incidence x-ray scattering (GISAXS) from the synchrotron source are suitable for this purpose because this source can produce a highly intense and focus x-ray. The structure of drug delivery systems with only small amount of samples can be determined. Very comprehensive information is the result. The further useful technique to determine the nanostructure is the small angle neutron scattering (SANS). Because of the opportunity to vary the contrast, different regions of the sample can be observed. However, these modern techniques can be performed only at the large scale facilities (synchrotron or neutron sources) e.g. Berlin Synchrotron Source (BESSY), German Synchrotron Source (DESY), Hahn-Meitner-Institute (BENSC), Heinz-Maier-Leibnitz (FRM II). The experiments can be carried out at these institutes on basis of a particular permission applied for together with a respective proposal. These techniques are until now mostly used in the field of physic, biology and chemistry. The present research work shows, however, that they are also useful as complementary techniques for pharmaceutical systems.


Nanotech 2008 Conference Program Abstract