Label-free and Real-Time Photonic Band-Gap Silica Nanosensor

Keywords:
label-free, interference, photonic, solica

Abstract:
We have developed an optical label-free biosensors which can provide easy, highly reproducible, and sensitive sensing assays for biomolecular reactions. The fabrication of the biosensor based on photonic band-gap silica is simple and compatible with conventional silicon microfabrication. The sensing signal of the photonic band-gap silica biosensor can be detected by both reflection and transmission mode. This flexibility gives the photonic band-gap silica biosensor more easily to integrate into silicon or glass based bio-microsystems. A wavelength shift of 30nm has been demonstrated by goat anti-h-IgG and 100ngmL-1 h-IgG recognition. The photonic band-gap silica nanosensor is promising as an easy and cost-effective alternative to conventional biosensing. Furthermore, it can be generally applied for the creation of colormetric sensors for many different analytes of choice.

Nanotech 2008 Conference Program Abstract