2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

Partnering Events:

TechConnect Summit
Clean Technology 2008

Multimodal and multifunctionality of Nanoparticles in Imaging

R. Sharma, C.J. Chen
Florida State University, US

Keywords:
polyamines, silica, gadolinium, mangnese, gold, calcium, bioimaging

Abstract:
Multimodal and multifunctional role of targeted nanoparticles has emerged as a potential tool in bioimaging by optical, PET, CT, MRI and therapeutics by nanoparticle cell specific ligand binding at cell receptors. Polyamine dendrimer, silica, gadolinium, gold have been extensively explored for their multimodal modes(monitoring disease, diagnosis, imaging) and multifunctionality(immunogenic, radio-opaque, paramagnetic)characteristics. Mostly a multimodal agent has fluorescent, optical, radio-opaque, magnetic properties. Examples are Ru:GdIII/SiO2 for CT-MRI-Optical; PEG-Gold NP for x-Ray-CT, double labeled 18F-19Fcomposites for PET/MRI. Recently, other less common techniques using Mangnese, calcium as channel markers, are in development stage for enhanced MRI and fluorescent imaging. Previously we reported nitroimidazole as hypoxia biosensor and diagnostic probe, antiamoebic and radiosensitizer to tumors. In conclusion, multifunctionality and multimodal use of nanoparticles serves as efficient approach oof less tissue damage, rapid, user-friendly tool in monitoring, diagnostic and therapeutics.


Nanotech 2008 Conference Program Abstract