2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

Partnering Events:

TechConnect Summit
Clean Technology 2008

Newer Nanoparticles in Hyperthermia Treatment and Thermometry

R. Sharma, C.J. Chen
Florida State University, US

Keywords:
tumor, oncology, hypoxia, hyperthermia, nanoparticles, nanothermal therapy

Abstract:
Heating tumors by nanoparticles and resistance in hypoxic tumor cells to high temperature is emerging as effective tool in therapeutic oncology as nanomedicine tool. Now art of imaging temperature in tumor at various locations is emerging as selective approach of hyperthermia to monitor temperature and treat the tumor. However, thermometry and tumor cell interaction with nanoparticles may monitor and evaluate the tumor cell survival after exposure to high physiological temperatures. The application of newer nanoparticles in tumor hyperthermia has emerged as effective monitoring tool as magnetic resonance (MR) thermal mapping. The temperature and nanoparticle magnetic moment relationship is specific in imaging. Two main issues are unsolved yet. First, the relationship of tumor energy changes due to tumor magnetization, linear attenuation after magnetic field and x-ray exposure with tissue temperature increase. Other issue is undefined behavior of nanoparticle inside tumor as diamagnetic or paramagnetic can be therapeutic and it depends on tumor tissue temperature. In vivo imaging such as MR thermometry mapping of different hypoxic tumor locations solves these issues to some extent. The art of nanoparticle induced hyperthermia has great impact on public health as alternative therapeutic oncology.


Nanotech 2008 Conference Program Abstract