2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

Partnering Events:

TechConnect Summit
Clean Technology 2008

Imaging with Phage Probes

K.A. Kelly
Harvard Medical School/MGH, US

Keywords:
phage imaging

Abstract:
Phage display technology provides a powerful approach for the rapid and cost effective discovery of lead compounds for development into targeted imaging agents. With this technique, targeting molecules with optimal in vivo pharmacokinetics, specificity, and affinity can be isolated. Interestingly, and most of all promising has been the utilization of phage themselves as nanoscaffolds for targeted imaging agents. Using the phage as nanoscaffolds carries several advantages namely 1. the phage are replenishable and cost effective and 2. the peptides are presented in the format in which they were originally screened for bioactivity, obviating the potential to lose the desired physiological properties through chemical synthesis of the peptides. Recently, selections have been performed in patients with melanoma, pancreatic, and breast cancers with no adverse affects, generating hope for the not too distant use of targeted phage as clinically relevant imaging agents.


Nanotech 2008 Conference Program Abstract