A Novel Nanoneedle Biosensor for DNA Sequencing
H. Esfandyarpour, R.W. Davis
Stanford University, US
nanoneedle, biosensor, DNA sequencing, optimization
We present and study of a novel Nanoneedle biosensor as an ultra sensitive and localized impedance biosensor. This preliminary study was performed to prove the feasibility of the impedance biosensor for detection of protein or nucleic acids. By monitoring the change in capacitance and impedance of this structure, we aim to characterize and classify biological species such as protein or nucleic acids as they are attached. Our geometry and monitoring approach aims to overcome some of the current limitations of biosensors. Impedance biosensors have enormous potential for point of care diagnostics; situations where low cost, small instrument size and speed of analysis are crucial. A finite element model was created using finite element COMSOL 3.3a to monitor the change in the some of the aforementioned properties of our device under different circumstances.
Nanotech 2008 Conference Program Abstract