Direct Patterning of oligonucleotides and nanoparticles on silicon surfaces

Keywords:
DPN, oligonucleotides, nanoparticles

Abstract:
We present a novel approach to pattern oligonucleotides and nanoparticles directly onto silicon substrates via Dip-Pen Nanolithography and microcontact printing techniques. The patterned oligonucleotides maintained their biological activity. The nanoparticles assembly was investigated for its electronic properties. The fabrication strategy we report does not require pre-modified substrates and offers a cheap and robust way to immobilize oligonucleotides or nanoparticles on electronically important semiconductor surfaces. The method can be utilized in the construction of novel structures and biosensors.

Nanotech 2008 Conference Program Abstract