2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

Partnering Events:

TechConnect Summit
Clean Technology 2008

Functional Nanoparticles for Biomedical Applications

Y. Durant, E. de Muinck
Nanostructured Polymers Research Center, US

Keywords:
targeted contrast agent, MRI, ultrasound, gene delivery, drug delivery, liposomes, nanoparticles, homing peptide

Abstract:
Nanoparticles are finding increasing applications in the areas of medical diagnostic and therapeutics. The following examples will be elaborated upon with an emphasis on synthesis. Diagnotics Targeted magnetic nanoparticle sensors for Magnetic Resonance Imaging of angiogenesis. Polymeric nanoparticles containing a core of magnetite (Fe3O4) are functionalized with polyethylene glycol and a NGR homing peptide. The PEG layer enhances circulation time in the blood, while NGR allows targeting of the nanoparticles to CD13/APN cell surface receptor, that are over expressed in areas of neo-vessels growth. This MRI contrast agent has clinical utility for the diagnosis of cardiac diseases. Targeted contrast agents for intravascular ultrasound imaging. Concurrently we are developing immuniliposomes that can be loaded with fluorobutane in order to generate microbubbles at the temperature of the human body. Additionally these nanoparticles are functionalized with a homing NGR peptide to improve clinical utility. Such contrast agent allow rapid diagnostic with advanced ultrasound devices. Therapeutics Targeted Gene Delivery of DNA to the ovarian cancer microenvironment. We synthesized immunonanoparticles based on a combination of 3 phospholipids by self and direct assembly. The immunoliposomes contain folded plasmid that codes for interleukin 18 and green fluorescent protein (GFP), folded on spermamine. The liposomes are functionalized with antiCD11c in order to target CD11c cell receptors that are over expressed in ovarian cancer cells. Targeted nanoparticle mediated drug delivery Triblock copolymers of polyethylene glycol, polylactic acid, polyglutamic acid are synthesized in order to create a nanocapsule with potential for drug delivery. These particles are further functionalized with a TAT peptide to increase cellular uptake.


Nanotech 2008 Conference Program Abstract