2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

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TechConnect Summit
Clean Technology 2008

Cytotoxicity of Nano-materials on Human Bronchial Epithelial Cell

D.C. Shin, J.Y. Jang, J.Y. Yang, S.H. Kim, I.H. Choi, Y.W. Lim, C.S. Kim, G.T. Lee
Yonsei University, KR

Keywords:
silver, Ag, carbon nanotube (CNT), apoptosis, cytokine, viability

Abstract:
This study was undertaken to address the current deficient knowledge of cellular response to nano sized particle exposure.[4] The aim of this study was to investigate the in vitro responses of human bronchial epithelial cells (BEAS-2B) after exposure to nano-materials (Ag and CNT). BEAS-2B cell viability decreased with decreasing doses of Ag (diameters : 40~70 and 100 nm) and MWCNT (diameters : 4~6 and 10~15 nm) nano-materials. At the higher exposure ( 200 ug/ml), all materials induced significant cell damage. Nano Ag materials increased apoptosis and cytokine expression (IL-6 and IL-8) when over 100 ug/ml concentration. All MWCNTs weakly increased apoptosis and did not significantly increased cytokine expression. In conclusion, we suggest that Ag and MWCNT nano-materials induce variable extents of cellular toxicity in a dose-dependent and size-dependent.


Nanotech 2008 Conference Program Abstract