2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

Partnering Events:

TechConnect Summit
Clean Technology 2008

Luminescent Nanosensors for Nerve Gas Agents

T. Gunasinghe, B. Sabacky, B. Marganski, M. Coleman, S. Muralidharan
Washington State University, US

Keywords:
nanosensor, bottom-up, isoquinoline, quartz

Abstract:
Chemical warfare agents are highly toxic to humans and animals. They are stable and easily dispersed, highly toxic and effect rapidly both when inhaled and absorbed through the skin. It is critical to have an effective sensor to protect civilians and military personnel from attack by nerve gas agents. We have developed nanosensors for the nerve gas agents consisting of four components; nanoparticle, fluorescent molecule, metal complex, and receptor molecules by step-by-step assembly of the moieties by bottom up approach. Incoming nerve gas agents will only associate with receptor molecule and signal transduction results emission change in whole sensor. This leads to fluorescence change over a large spectral window leading to a very low detection limit. The first generation of sensors is prone to degradation from effect of foreign substances, heat or cold because of their very high sensitivity and then we moved to more selective and stable metal ion complexes. Already we have developed a compound library for potential nanosensor. The results of these studies will be presented.


Nanotech 2008 Conference Program Abstract