2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

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TechConnect Summit
Clean Technology 2008

Effect of surfactants on the size-distribution of starch nanoparticles during wet grinding

N.I. Bukhari, Y.B. Kang, Y.K. Hay, A.B.A. Majeed, M. Nadeem, S.H. Bai
International Medical University, MY

Keywords:
surfactants, starch, nanoparticles

Abstract:
1School of Pharmacy, International Medical University, Kuala Lumpur, 2School of Pharmaceutical Sciences, University Science Malaysia, Penang, 3Faculty of Pharmacy, University Technology MARA, Kuala Lumpur. 4Chemcial Engineering Department, University Technology PETRONAS, Perak, Malaysia. Abstract: Various kinds of conventional and non-conventional surfactants were utilized for the fabrication of nanoparticles of starch and to reduce the size distribution. The surfactants used were pluronic F-68, span 80, span 20, Aerosol TR (ATR) and Aerosol OT (AOT). Starch in premix form with either of the surfactants 0.5 to 2 % were administered to Netsch MiniCerĀ® laboratory circulation machine (Netsch, Germany). The speed was adjusted to 1500 rpm (25 Hz). Zicronium beads of 1mm diameter were used as a grinding media. Pluronic F-68 1% reduced the starch particle size to minimum level (353.33 nm) with 1 hr grinding time. Whereas, other surfactants used at this speed could reduce the size to or above 399 nm. However, at 0.5 hr grinding time, 0.5% pluronic reduced the size to 335.00nm. The other surfactants at this speed yielded particle size equal to or above 382 nm. Pluronic demonstrated the highest efficiency in size reduction followed by ATR-AOT (1:4) combination.


Nanotech 2008 Conference Program Abstract