Targeting bacterial infection with 99mTc Cyclodextrin
G.P. Bandopadhyaya, J. Shukla
All India Institute of Medical Sciences, IN
cyclodextrin, infection, Autodock, radiochemical purity
Molecular interaction between host mucosal surfaces and outer membrane components of microbes is crucial for the establishment of infection. Maltodextrin binding protein (MBP) acts as the initial component for active transport and bacterial chemotaxis. The Technetium-99m labeled beta-HPCD formulation was localized after intra venous (i.v.) injection in the infection site using gamma camera. The computational autodocking also demonstrated and confirmed the binding of beta-HPCD to MBP of bacteria. Our clinical and computational studies demonstrated that the radiolabeled beta-HPCD could be used as diagnostic tool for bacterial infections.
Nanotech 2008 Conference Program Abstract