2008 NSTI Nanotechnology Conference and Trade Show - Nanotech 2008 - 11th Annual

Partnering Events:

TechConnect Summit
Clean Technology 2008

The Use of Gold-Citrate Nanoparticles and Curcumin Nanomedicine to Target Cancer at a Single Cell Level

A. Moten
Harvard University, US

Keywords:
gold-citrate nanoparticles, cancer, extracellular matrix

Abstract:
Nanorobotics nvolve the use of chemical assemblies to nanomanipulate cellular behavior. In order to target cancer at a single cell level, Gold-Citrate Nan particles were synthesized with the the Gaussian distribution of diameters of 13 nm. Gold Nanoparticles, which adversely effects normal cells, were coated with sodium citrate. Past research has demonstrated that cancerous cells are more prone to absorb nanomaterials coated with citrate than normal somatic cells. The results professed that when normal cells were exposed to Au particles, the damage was reversible and that the dermal fibroblast cells were able to regenerate stress fibers which were lost during exposure. However, cancer cells were unable to recover from the damage inflicted by Au/citrate nanoparticle exposure. Moreover, the effects of herbal medicine nanostructural chemical assemblies was studied on human hepatocellular carcinoma. Curcumin, the yellow pigment of turmeric or haldi, has received attention as a promising dietary supplement for cancer prevention and treatment. This study demonstrates that curcumin nanoassemblies human hepatocellular carcinoma growth.


Nanotech 2008 Conference Program Abstract